Minoxodil, a vasodilator, C 9 H 15 N 5 O, administered orally for the treatment of hypertension marketed as Lotinen  was first developed in the 1970's as a blood pressure medication  because of its ability to cause blood vessels to dilate. However, some patients began noticing an interesting side effect: their facial hair began to thicken, and in some cases thickening was noted in previously balding scalp tissue.

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